We give a rigorous derivation of the Hartree equation for the many-body dynamics of pseudo-relativistic Fermi systems at high density \varrho \gg 1, on arbitrarily large domains, at zero temperature. With respect to previous works, we show that the many-body evolution can be approximated by the Hartree dynamics locally, proving convergence of the expectation of observables that are supported in regions with fixed volume, independent of ϱ. The result applies to initial data describing fermionic systems at equilibrium confined in arbitrarily large domains, under the assumption that a suitable local Weyl-type estimate holds true. The proof relies on the approximation of the initial data through positive temperature quasi-free states, that satisfy strong local semiclassical bounds, which play a key role in controlling the growth of the local excitations of the quasi-free state along the many-body dynamics.