We investigate for the first time weak lensing in a high-resolution relativistic N-body simulation, which includes all relevant effects from general relativity. We integrate the photon geodesics backwards from the observer to the emitters. Our analysis is fully relativistic and non-perturbative for the scalar part of the gravitational potential and first-order in the vector part, frame dragging. We solve the Sachs optical equations and study in detail the weak-lensing convergence, ellipticity and rotation. We present the angular power spectra and one-point probability distribution functions for the weak-lensing variables, which we find are broadly in agreement with comparable Newtonian simulations. Our geometric approach, however, is more robust and flexible, and can therefore be applied consistently to non-standard cosmologies and modified theories of gravity.